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KMID : 0870420120160010024
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Korean Journal of Hepato-Biliary-Pancreatic Surgery
2012 Volume.16 No. 1 p.24 ~ p.28
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Clinical outcome and long term results after surgical treatment of biliary cystadenoma and cystadenocarcinoma
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Song Young-Peck
Kang Mee-Joo
Jang Jin-Young
Lee Kuhn-Uk
Suh Kyung-Suk
Kim Sun-Whe
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Abstract
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Background/Aims: Biliary cystadenoma (BCA) and cystadenocarcinoma (BCCA) are rare cystic hepatic neoplasms. Prior reports concerning the proper surgical treatment and long-term survival are scarce. We report our experience and survival outcome of 30 patients over the last 25 years.
Methods: We retrospectively reviewed the clinicopathologic data of the pathologically confirmed 18 BCA and 12 BCCA patients, who underwent operations from 1983 to 2006, at the Seoul National University Hospital.
Results: The patients consisted of 8 men and 22 women with a mean age of 51 years. With abdominal computed tomography scans, 73.3% (n=22) were preoperatively diagnosed as BCA or BCCA, and differentiating BCCA from BCA was accurate in 58.3% patients. R0 resection was achieved in 90% (n=27). The differentiating factors included the presence of mural nodule (4/18 vs. 8/12; p=0.009) and mucinous content (2/9 vs. 8/1; p=0.005), and tumor size tending to be larger in BCCA (11.7 cm vs. 7.9 cm; p=0.067). Overall 5-year and 10-year survival rates of BCCA were 72.9% and 60.9%, respectively. Of patients with BCCA, 4 experienced recurrence. In case of recurrence, patients tended to be younger than 50 years (p=0.061) and the lesions tended to be larger than those without recurrence (p=0.088).
Conclusions: Preoperative differentiations of BCA from simple cyst, and BCCA from BCA are still difficult. Complete removal of the tumor, via major hepatectomy, should be considered, especially in the younger age group with large tumor.
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KEYWORD
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Biliary tract, Cyatadenoma, Cystadenocarcinoma, Survival rate, Malignancy
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